About Gut-Research

Research group within the Tytgat Institute for Liver and Intestinal Research in Amsterdam

Colorectal cancer treatment and post-operative care for cancer patients

Service Overview

At Gut-Research, we focus on advancing the treatment and post-operative care of colorectal cancer patients. Our research centers on improving surgical outcomes, particularly in preventing and addressing complications such as anastomotic leakage (AL), a common and serious issue following colorectal surgery. By understanding the cellular and molecular mechanisms behind wound healing, we aim to reduce the high morbidity and mortality rates associated with these complications.

We combine preclinical and clinical research to explore innovative solutions that enhance wound healing, improve post-surgery recovery, and ultimately lead to better outcomes for colorectal cancer patients.

Our Capabilities

Gut-Research offers a comprehensive range of services for colorectal cancer research, focusing on post-surgical care and therapeutic development. Our cutting-edge research tools and expert team allow us to delve into the intricacies of wound healing and cancer treatment. Key capabilities include:

  • Anastomotic healing research: We investigate the early processes involved in anastomotic healing (AH) to understand the factors that contribute to complications like anastomotic leakage. Our aim is to reduce the risks of these complications through improved surgical techniques and treatments.

  • Preclinical and clinical models: We utilize a variety of preclinical models and clinical research methods to study surgical complications and wound healing. These models help us uncover key mechanisms involved in tissue repair and regeneration following colorectal surgery.

  • Personalized post-operative care: Based on our research, we develop personalized therapeutic approaches to enhance post-surgery recovery, reduce the risks of complications, and improve the quality of life for colorectal cancer patients.

Our research into colorectal cancer treatment and post-operative care is designed to provide innovative solutions for enhancing surgical outcomes and reducing complications such as AL. By addressing both the biological and clinical challenges, we aim to improve the standard of care for colorectal cancer patients.

In collaboration with Health Holland and MRM Health, the MICROPIAL project studies how probiotics can influence wound healing and anastomosis following cancer surgery. This research aims to improve post-operative recovery by altering the microbiome’s role in healing. Learn more about our work at Health Holland and MRM Health.
Funded by the EU JPI, the METARYL project explores how tryptophan, a key nutritional component, affects wound healing and the development of infections in diabetic patients. This research has direct implications for post-operative care in colorectal cancer patients as well. For more details, visit METARYL.

Partner with us in IBS Research

Gut-Research is committed to improving colorectal cancer treatment and post-operative care through innovative research and collaboration. We invite academic institutions, healthcare providers, and industry partners to collaborate with us in developing new therapies and improving surgical outcomes for cancer patients.

By partnering with us, you gain access to our advanced research methods, expert team, and state-of-the-art facilities. Together, we can explore the cellular and molecular aspects of wound healing and enhance post-operative care for colorectal cancer patients. Contact us today to learn more about collaboration opportunities and how Gut-Research can support your cancer research projects.