About Gut-Research

Research group within the Tytgat Institute for Liver and Intestinal Research in Amsterdam

Contact Info

info@gut-research.com

+31 20 566 8156

Meibergdreef 69, 1105 BK Amsterdam

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Join the Gut-Research team

Background

At Gut Research, we are keen to meet a postdoc and/or PhD fellow candidate for exciting opportunities to join the inflammatory bowel disease (IBD) research team at the Tytgat Institute and the Department of Gastroenterology at the AmsterdamUMC. Inflammatory bowel disease (IBD) constitutes a group of incurable, chronic, relapsing diseases of the gastrointestinal tract, stemming from a dysregulated interplay between the environment and the immune system in genetically susceptible individuals. We are seeking a skilled Postdoc/PhD with a passion for leveraging computational approaches to understand the molecular mechanisms underlying IBD and its phenotypes. In this role, you will collaborate closely with our interdisciplinary team of clinicians, geneticists, and molecular biologists to analyze large-scale omics datasets, including genomics, transcriptomics, proteomics, and microbiome data.

What tasks will you undertake?

Our earlier projects have generated a better understanding of the analyses of high-dimensional data in personalized approaches to IBD treatment. The ideal candidate will be able to:

  • Work with in-house generated or publicly available genetic, epigenetic, transcriptomic, proteomic data at bulk and single-cell level.
  • Aid in the development pipelines for analyzing high-dimensional biological data. Perform data preprocessing, quality control, and normalization on omics datasets for Biomarker identification and Molecular pathways analyses.
  • Be able to work on Multi-omics data integration. Be able to master Data visualization techniques to communicate findings effectively to both technical and non-technical stakeholders.
  • Apply (epi)genetic approaches to cells and tissue systems to study mechanistic aspects of IBD and its treatment. You will work within the epigenetic team over spanning gut Research laboratory and UvA Swammerdam Institute of Life Sciences  

Who will be your colleagues?

You will be collaborating with researchers at the Tytgat Institute for Liver and Intestinal Research and the Department of Gastroenterology at the AmsterdamUMC as well as UvA Swammerdam Institute of Life Sciences (SILS) where needed. Departments are all located in Amsterdam and home to dedicated researchers engaged in fundamental, applied, and clinical research within the fields of gastroenterology and hepatology. The candidate will be actively involved in facilitating projects in the context of inflammatory bowel disease.

Candidate profile

  • You possess a master’s degree in biomedical data sciences or a related life-science field with experience in applied data analysis.
  • You have prior experience in analyzing omics data, such as (single-cell/bulk) RNA-sequencing, DNA methylation microarrays, or metagenomics sequencing. Previous exposure to single-cell omics technologies, such as single-cell RNA-sequencing, is a pre.
  • Proficiency in R, Python, and bash scripting, along with familiarity working in a Linux environment using schedulers, is expected.
  • Good verbal communication skills in English are essential.
  • You are inherently driven, scientifically curious, and adept at collaborative teamwork.
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